Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease - Druckversion

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+---- Thema: Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease (/showthread.php?tid=2482)

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Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease - Sunflower - 29.05.2013

Ticks Tick Borne Dis. 2012 Jun;3(3):193-6. doi: 10.1016/j.ttbdis.2012.01.001. Epub 2012 Mar 13.

Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease prevention: an animal model.

Piesman J, Hojgaard A.

Zitat:We found that two treatments of doxycycline delivered by oral gavage to mice on the day of removal of a single potentially infectious nymphal I. scapularis protected 74% of test mice compared to controls.

When treatment was delayed until 24 h after tick removal, only 47% of mice were protected;

prophylactic treatment was totally ineffective when delivered ≥2 days after tick removal.

Although the dynamics of antibiotic treatment in mice may differ from humans, and translation of animal studies to patient management must be approached with caution, we believe our results emphasize the point that antibiotic prophylactic treatment of tick bite to prevent Lyme disease is more likely to be efficacious if delivered promptly after potentially infectious ticks are removed from patients.

There is only a very narrow window for prophylactic treatment to be effective post tick removal.

http://www.ncbi.nlm.nih.gov/pubmed/22421585

J Med Microbiol. 2008 Apr

A sustained-release formulation of doxycycline hyclate (Doxycyclin) prevents simultaneous infection of Anaplasma phagocytophilum and Borrelia burgdorferi transmitted by tick bite.

Zeidner NS, Massung RF, Dolan MC, Dadey E, Gabitzsch E, Dietrich G, Levin ML.

Zitat:This study compared the efficacy of a single oral dose of doxycycline with that of a single injection of sustained-release doxycycline in a model of Lyme borreliosis and Anaplasma phagocytophilum infection.
(...)
In challenge experiments where five Borrelia burgdorferi-infected and five A. phagocytophilum-infected nymphs were used per mouse, only 20 and 30 % of mice were protected from B. burgdorferi and A. phagocytophilum infection, respectively, using oral doxycycline.

In contrast, 100 % of mice receiving sustained-release doxycycline were protected from A. phagocytophilum infection, as indicated by real-time PCR of blood samples, quantitative PCR and culture isolation of spleen samples, and protected against B. burgdorferi infection as demonstrated by culture of ear, heart and bladder.
(...)
These studies indicate that a single injection of a sustained-release formulation antibiotic may offer a viable prophylactic treatment option for multiple infectious agents in patients presenting with tick bites.

http://www.ncbi.nlm.nih.gov/pubmed/18349366

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RE: Protective value of prophylactic antibiotic ..... - Ehemaliges Mitglied - 09.06.2013

Eine kleine Hilfe zu #1
http://translate.google.de/translate?sl=en&tl=de&js=n&prev=_t&hl=de&ie=UTF-8&u=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22421585

http://translate.google.de/translate?sl=en&tl=de&js=n&prev=_t&hl=de&ie=UTF-8&u=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F18349366

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RE: Protective value of prophylactic antibiotic treatment of tick bite for Lyme - Regi - 10.06.2013

Mein English ist ja ganz schlecht und Google-Translator liefert mir auch keine Antwort:
Wie konnte zuverlässig festgestellt werden, ob eine Infektion stattgefunden hat oder nicht? Frühe Therapien können beim Menschen die Antikörperproduktion hemmen. Werden bei Mäusen Antikörper gemessen? Oder wie sonst wird der Therapieerfolg kontrolliert?
Läuft die Borrreliose bei Mäusen auch in Stadien ab? Teilweise mit latenten Phasen?

LG, Regi

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