Possible factors contributing to persistence of organisms - Druckversion

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Possible factors contributing to persistence of organisms - Luna - 21.10.2012

Hum Pathol. 1996 Oct;27(10):1025-34

Ultrastructural demonstration of spirochetal antigens in synovial fluid and synovial membrane in chronic Lyme disease: possible factors contributing to persistence of organisms

Nanagara R, Duray PH, Schumacher HR Jr.

Allergy-Immunology-Rheumatology Division, Department of Medicine, Faculty of Medicine, KhonKaen University, Thailand.

[From the abstract:] “Electron microscopy [both EM and IEM were used] adds further evidence for persistence of spirochetal antigens in the joint in chronic Lyme disease. Locations of spirochetes or spirochetal antigens both intracellulary and extracellulary in deep synovial connective tissue as reported here suggest sites at which spirochaetes may elude host immune response and antibiotic treatment
.”

[From the article:] “If spirochetes are already sequestered in tissue that is inaccessible to antibiotics such as in the fibrinous and collagen tissue or within fibroblasts, high-dose parenteral antibiotics, or combination therapies with long duration may be needed to kill the living spirochetes.” (p.1032)
PMID: 8892586 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/8892586

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