Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia bu - Druckversion

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Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia bu - landei - 22.10.2012

Persistenz von Immunglobulin M oder Immunglobulin G Antikörpern auf Borrelia burgdorferi 10-20 Jahre nach einer aktiven Lyme-Borreliose

Persistence of Immunoglobulin M or Immunoglobulin G Antibody Responses to Borrelia burgdorferi 10–20 Years after Active Lyme Disease


Robert A. Kalish, Gail McHugh, John Granquist, Barry Shea, Robin Ruthazer and Allen C. Steere

The interpretation of serological results for patients who had Lyme disease many years ago is not well defined. We studied the serological status of 79 patients who had had Lyme disease 10–20 years ago and did not currently have signs or symptoms of active Lyme disease. Of the 40 patients who had had early Lyme disease alone, 4 (10%) currently had IgM responses to Borrelia burgdorferi, and 10 (25%) still had IgG reactivity to the spirochete, as determined by a 2-test approach (enzyme-linked immunosorbent assay and Western blot). Of the 39 patients who had had Lyme arthritis, 6 (15%) currently had IgM responses and 24 (62%) still had IgG reactivity to the spirochete. IgM or IgG antibody responses to B. burgdorferi may persist for 10–20 years, but these responses are not indicative of active infection.

http://cid.oxfordjournals.org/content/33/6/780.full

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