[Sunflower]

Curcumin zeigte in anderen in vitro Studien eine synergistische Wirkung mit manchen AB gegen andere Bakterien!

Biomed Res Int. 2014;2014:561456. doi: 10.1155/2014/561456. Epub 2014 May 18.

In vitro synergistic effect of curcumin in combination with third generation cephalosporins against bacteria associated with infectious diarrhea.

Sasidharan NK1, Sreekala SR2, Jacob J1, Nambisan B2.

http://www.ncbi.nlm.nih.gov/pubmed/24949457

In the checkerboard test, curcumin-1 markedly reduced the MICs of the antibiotics cefaclor, cefodizime, and cefotaxime. Significant synergistic effect was recorded by curcumin-1 in combination with cefotaxime.

(...). From our result it is evident that curcumin-1 enhances the antibiotic potentials against diarrhea causing bacteria in in vitro condition. This study suggested that curcumin-1 in combination with antibiotics could lead to the development of new combination of antibiotics against diarrhea causing bacteria.

Phytomedicine. 2013 Jun 15;20(8-9):714-8. doi: 10.1016/j.phymed.2013.02.006. Epub 2013 Mar 26.

Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus.

Mun SH1, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, Kim YC, Lee DS, Shin DW, Kweon KT, Kwon DY.

http://www.ncbi.nlm.nih.gov/pubmed/23537748

In the checkerboard test, CCM markedly reduced the MICs of the antibiotics oxacillin (OXI), ampicillin (AMP), ciprofloxacin (CIP), and norfloxacin (NOR) used against MRSA. The time-kill curves showed that a combined CCM and OXI treatment reduced the bacterial counts below the lowest detectable limit after 24h. This study suggested that CCM reduced the MICs of several antibiotics tested, notably of OXI, AMP, CIP, and NOR, and that CCM in combination with antibiotics could lead to the development of new combination of antibiotics against MRSA infection.

Curcumin hat in dieser in vitro Studie die minimalen Hemmkonzentrationen der AB gegen MSRA reduziert. Dies bedeutet, dass geringere AB Konzentrationen in Anwesenheit von Curcumin in vitro notwendig waren, um das Wachstum der Bakterien zu hemmen. Die Kombination AB + Curcumin reduzierte die Bakterienzahl unterhalb der Nachweisgrenze nach 24 Std. [Merke: dies gilt für planktonische, frei schwimmende Bakterien, nicht für Biofilme!!!]

Die Frage ist, ob Curcumin in vivo diese synergetische Wirkung mit diesen AB auch hätte!