[Sunflower]

In dieser in vivo Studie hemmte Curcumin ebenfalls die Wirkung der AB und förderte das Bakterienwachstum von Salmonellen (wie in der vorher geposteten Studie):

PLoS One. 2010 Jul 9;5(7):e11511. doi: 10.1371/journal.pone.0011511.

Curcumin increases the pathogenicity of Salmonella enterica serovar Typhimurium in murine model.

Marathe SA1, Ray S, Chakravortty D.

http://www.ncbi.nlm.nih.gov/pubmed/20634977

Curcumin has gained immense importance for its vast therapeutic and prophylactic applications. Contrary to this, our study reveals that it regulates the defense pathways of Salmonella enterica serovar Typhimurium (S. Typhimurium) to enhance its pathogenicity. In a murine model of typhoid fever, we observed higher bacterial load in Peyer's patches, mesenteric lymph node, spleen and liver, when infected with curcumin-treated Salmonella. Curcumin increased the resistance of S. Typhimurium against antimicrobial agents like antimicrobial peptides, reactive oxygen and nitrogen species.
(...)
This data urges us to rethink the indiscriminate use of curcumin especially during Salmonella outbreaks.

Offensichtlich scheint die Kombination Curcumin + AB bei Infektionen mit Salmonellen kontraproduktiv zu sein.

Ob diese kontraproduktive Wirkung auch für Borrelien und Co-Infektionen gilt, müsste untersucht werden.

Interessant ist ebenfalls, dass Curcumin in vitro eine Wirkung gegen Quorum sensing und Biofilme mancher Bakterien hat:

Appl Microbiol Biotechnol. 2013 Dec;97(23):10177-87. doi: 10.1007/s00253-013-4704-5. Epub 2013 Jan 26.

Prevention of quorum-sensing-mediated biofilm development and virulence factors production in Vibrio spp. by curcumin.

Packiavathy IA1, Sasikumar P, Pandian SK, Veera Ravi A.

http://www.ncbi.nlm.nih.gov/pubmed/23354447

The obtained results evidenced 88% reduction in bioluminescence of Vibrio harveyi by curcumin. Further, curcumin exhibited a significant inhibition in alginate, exopolysaccharides, motility, biofilm development and other virulence factors production in Vibrio parahaemolyticus, Vibrio vulnificus and V. harveyi. In in vivo analysis, curcumin enhanced the survival rate of Artemia nauplii up to 67% against V. harveyi infection by attenuating its QS-mediated virulence.

Curcumin reduzierte die Biolumineszenz (=Indiz für Virulence!) von Vibrio h. um 88%. Curcumin zeigte auch eine hemmende Wirkung auf die Biofilme dieses Bakterium und anderen Virulenzfaktoren. In vivo erhöhte Curcumin die Überlebensrate des Salzwasserkrebses Artemia n. um 67%, indem es die Quorum sensing vermittelte Virulenz reduzierte.

Food Chem. 2014 Apr 1;148:453-60. doi: 10.1016/j.foodchem.2012.08.002. Epub 2012 Aug 10.

Inhibition of biofilm development of uropathogens by curcumin - an anti-quorum sensing agent from Curcuma longa.

Packiavathy IA1, Priya S, Pandian SK, Ravi AV.

Urinary tract infection is caused primarily by the quorum sensing (QS)-dependent biofilm forming ability of uropathogens. In the present investigation, an anti-quorum sensing (anti-QS) agent curcumin from Curcuma longa (turmeric) was shown to inhibit the biofilm formation of uropathogens, such as Escherichia coli, Pseudomonas aeruginosa PAO1, Proteus mirabilis and Serratia marcescens, possibly by interfering with their QS systems. The antibiofilm potential of curcumin on uropathogens as well as its efficacy in disturbing the mature biofilms was examined under light microscope and confocal laser scanning microscope. The treatment with curcumin was also found to attenuate the QS-dependent factors, such as exopolysaccharide production, alginate production, swimming and swarming motility of uropathogens. Furthermore, it was documented that curcumin enhanced the susceptibility of a marker strain and uropathogens to conventional antibiotics

Hier konnte Curcumin mit dem QS Systems und somit mit der Bildung von Biofilmen interferieren. Es erhöhte ebenfalls die Empfindlichlkeit eines Spezies und Uropathogenen zu AB.

Das ist übrigens Artemia...die hat meine Tochter in der Küche gezüchtet!

http://www.brineshrimpdirect.com/content...photo2.jpg

Leider ist die Vase ein Mal umgekippt, ich konnte die armen Tierchen nicht mehr retten...