[Markus]

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic Review, BMJ Open 2016;6:e010401 doi:10.1136/bmjopen-2015-010401

Conclusions High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis. Moreover, our study provides the rationale for a re-evaluation of guidelines recommending pharmacological reduction of LDL-C in the elderly as a component of cardiovascular disease prevention strategies.

Aus dem Abstract:

- es gibt einen inversen Zusammenhang zwischen der Höhe des LDL Cholesterins und der Sterblichkeit bei den meisten über 60 Jährigen
- dies widerspricht der Cholesterinhypothese
- die Reduktion von LDL-Cholesterin als Präventionsstrategie bei Älteren muss re-evaluiert werden