[Sunflower]

An in vitro evaluation of antibiotic susceptibility of two morphological forms of Borrelia burgdorferi

Kaur Navroop M.S.1,Datar Akshita B.S.1, Luecke David F B.S. 1, Sapi Eva Ph.D1

Lyme Disease Research Group, Department of Biology and Environmental Sciences, University of New Haven, CT, 06516

In dieser in vitro Untersuchung war Hydroxychloroquin (Markename Plaquenil) gegen Zysten von Borrelia burgdorferi nicht wirksam.Hydroxychloroquin förderte sogar die Bildung von Zysten:

All the drugs tested resulted in significant reduction of spirochete population of Bb, when administered alone or in combination but some of the drugs like doxycycline and plaquenil significantly increased the cyst forms of Bb.

http://www.newhaven.edu/257045.pdf

Effective Antimicrobials for the Different Forms of Borrelia burgdorferi

Priyanka A.S Theophilus M.S.1,Divya Burugu B.S.1, Akhila Poururi B.S.1, Daniel S Phillips B.S.1, David F. Luecke B.S.1,
Eva Sapi Ph.D1

http://www.newhaven.edu/475553.pdf

HCQ at high concentration (20 μg/ml) reduced the spirochete forms by 40% and the round bodies by 82%.
(...)
When quantitative effects on biofilm were evaluated, the four antibiotics reduced the formation of colonies by 29‐37%.

HCQ = Hydroxychloroquin

Hydroxychloroquin zeigte in dieser in vitro Untersuchung in hoher Konzentration (20 µg/ml) eine Reduzierung der Zystenzahl um 82%.

Die 4 Antibiotika reduzierten die Bildung der Kolonien um 29-37% (Doxycycline + HCQ 37%).