[Sunflower]

Grapefruit, orange, and apple juices decreased the fexofenadine area under the plasma concentration-time curve (AUC), the peak plasma drug concentration (C(max)), and the urinary excretion values to 30% to 40% of those with water, with no change in the time to reach C(max), elimination half-life, renal clearance, or urine volume in humans. Change in fexofenadine AUC with juice was variable among individuals and inversely dependent on value with water.

CONCLUSIONS:

Fruit juices and constituents are more potent inhibitors of OATPs than P-glycoprotein activities, which can reduce oral drug bioavailability. Results support a new model of intestinal drug absorption and mechanism of food-drug interaction.

Grapefruit-, Orange-und Apfelsaft reduzierten die Serumkonzentrazion von Fexofenadine (ein Antiallergikum) um 30 bis 40% in Vergleich zu der Einnahme mit Wasser.

http://www.ncbi.nlm.nih.gov/pubmed/11823753/