Eine Studie mit Fibromyalgie Patienten hat eine positive Wirkung (Schmerzreduktion um 28% ) bei 32% der Patienten festgestellt:
http://www.lowdosenaltrexone.org/ldn_trials.htm
Arthritis & Rheumatism
Volume 65, Issue 2, pages 529–538, February 2013
Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels
Jarred Younger, Noorulain Noor, Rebecca McCue, Sean Mackey [Stanford University]
http://www.lowdosenaltrexone.org/ldn_trials.htm
Arthritis & Rheumatism
Volume 65, Issue 2, pages 529–538, February 2013
Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels
Jarred Younger, Noorulain Noor, Rebecca McCue, Sean Mackey [Stanford University]
Zitat:To determine whether low dosages (4.5 mg/day) of naltrexone reduce fibromyalgia severity as compared with the nonspecific effects of placebo.
(...)
When contrasting the condition end points, we observed a significantly greater reduction of baseline pain in those taking low-dose naltrexone than in those taking placebo (28.8% reduction versus 18.0% reduction; P = 0.016). Low-dose naltrexone was also associated with improved general satisfaction with life (P = 0.045) and with improved mood (P = 0.039), but not improved fatigue or sleep. Thirty-two percent of participants met the criteria for response (defined as a significant reduction in pain plus a significant reduction in either fatigue or sleep problems) during low-dose naltrexone therapy, as contrasted with an 11% response rate during placebo therapy (P = 0.05). Low-dose naltrexone was rated equally tolerable as placebo, and no serious side effects were reported.
Conclusion
The preliminary evidence continues to show that low-dose naltrexone has a specific and clinically beneficial impact on fibromyalgia pain. The medication is widely available, inexpensive, safe, and well-tolerated.
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