Hallo,
beim Durchlesen folgender Studie habe ich wie beigefügt eine Korrektur gefunden. Was bedeutet das nun hinsichtlich dem Ergebnis? Ich kann das leider nicht richtig verstehen.
9 Apr 2012: Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, et al. (2012) Correction: Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection. PLOS ONE 7(4): 10.1371/annotation/4cafed66-fb84-4589-a001-131d9c50aea6. doi: 10.1371/annotation/4cafed66-fb84-4589-a001-131d9c50aea6 View correction
Abstract
The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The studies presented here explore antibiotic efficacy using nonhuman primates. Rhesus macaques were infected with B. burgdorferi and a portion received aggressive antibiotic therapy 4–6 months later. Multiple methods were utilized for detection of residual organisms, including the feeding of lab-reared ticks on monkeys (xenodiagnosis), culture, immunofluorescence and PCR. Antibody responses to the B. burgdorferi-specific C6 diagnostic peptide were measured longitudinally and declined in all treated animals. B. burgdorferi antigen, DNA and RNA were detected in the tissues of treated animals. Finally, small numbers of intact spirochetes were recovered by xenodiagnosis from treated monkeys. These results demonstrate that B. burgdorferi can withstand antibiotic treatment, administered post-dissemination, in a primate host. Though B. burgdorferi is not known to possess resistance mechanisms and is susceptible to the standard antibiotics (doxycycline, ceftriaxone) in vitro, it appears to become tolerant post-dissemination in the primate host. This finding raises important questions about the pathogenicity of antibiotic-tolerant persisters and whether or not they can contribute to symptoms post-treatment.
Correction:Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection
Published: September 24, 2013
http://dx.doi.org/10.1371/annotation/f84...58133c1b0f
In the Results section of the article, the first paragraph under the heading "Monitoring of infection status postmortem." had an error in its last sentence as a result of issues in the typesetting process. The correct sentence is available below. "With regard to culture of spirochetes, none of the treated animals yielded a positive culture and only one of the untreated animals was culture-positive (lung tissue)."
Wie gesagt, hier verstehe ich nur Bahnhof, wäre toll, wenn hier jemand Klarheit reinbringen könnte.
Liebe Grüße,
IrisBeate
beim Durchlesen folgender Studie habe ich wie beigefügt eine Korrektur gefunden. Was bedeutet das nun hinsichtlich dem Ergebnis? Ich kann das leider nicht richtig verstehen.
9 Apr 2012: Embers ME, Barthold SW, Borda JT, Bowers L, Doyle L, et al. (2012) Correction: Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection. PLOS ONE 7(4): 10.1371/annotation/4cafed66-fb84-4589-a001-131d9c50aea6. doi: 10.1371/annotation/4cafed66-fb84-4589-a001-131d9c50aea6 View correction
Abstract
The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The studies presented here explore antibiotic efficacy using nonhuman primates. Rhesus macaques were infected with B. burgdorferi and a portion received aggressive antibiotic therapy 4–6 months later. Multiple methods were utilized for detection of residual organisms, including the feeding of lab-reared ticks on monkeys (xenodiagnosis), culture, immunofluorescence and PCR. Antibody responses to the B. burgdorferi-specific C6 diagnostic peptide were measured longitudinally and declined in all treated animals. B. burgdorferi antigen, DNA and RNA were detected in the tissues of treated animals. Finally, small numbers of intact spirochetes were recovered by xenodiagnosis from treated monkeys. These results demonstrate that B. burgdorferi can withstand antibiotic treatment, administered post-dissemination, in a primate host. Though B. burgdorferi is not known to possess resistance mechanisms and is susceptible to the standard antibiotics (doxycycline, ceftriaxone) in vitro, it appears to become tolerant post-dissemination in the primate host. This finding raises important questions about the pathogenicity of antibiotic-tolerant persisters and whether or not they can contribute to symptoms post-treatment.
Correction:Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection
Published: September 24, 2013
http://dx.doi.org/10.1371/annotation/f84...58133c1b0f
In the Results section of the article, the first paragraph under the heading "Monitoring of infection status postmortem." had an error in its last sentence as a result of issues in the typesetting process. The correct sentence is available below. "With regard to culture of spirochetes, none of the treated animals yielded a positive culture and only one of the untreated animals was culture-positive (lung tissue)."
Wie gesagt, hier verstehe ich nur Bahnhof, wäre toll, wenn hier jemand Klarheit reinbringen könnte.
Liebe Grüße,
IrisBeate
Absence of proof is not proof of absence (William Cowper).