05.07.2015, 11:28
Die Gruppe von Lewis will die gepulste Therapie nun in vivo in Tieren und Menschen testen ("The Northeastern researchers published the results this month in the journal Antimicrobial Agents and Chemotherapy. They’re now planning to collaborate on studies to test the dosing regime in animals and humans.")
Die Dauer und Pausen der Perioden scheinen anders zu sein als bisher verwendete Pulsschemata. ("The dosing schedule that the Lewis lab used, she notes, is very different from what some doctors have been prescribing Lyme disease patients for years. Some have used a pulse approach, she says, 'because we’ve known for a long time that these bacteria go into hiding, and it was just a common-sense concept that you let them go dormant and when they come back up again, you hit them again.' But 'the ‘off’ period may have been too long in humans,' Dr. Kotsoris says, and that could be why the pattern didn’t help some patients.") Wobei natürlich das optimale Timing in vitro anders sein kann als in vivo.
Quelle: In Test Tube, ‘Pulse-Doses’ Of Antibiotic Wipe Out Lyme Disease Bacteria Persisters, June 12, 2015, Carey Goldberg, http://commonhealth.wbur.org/2015/06/lym...ster-pulse
Die Dauer und Pausen der Perioden scheinen anders zu sein als bisher verwendete Pulsschemata. ("The dosing schedule that the Lewis lab used, she notes, is very different from what some doctors have been prescribing Lyme disease patients for years. Some have used a pulse approach, she says, 'because we’ve known for a long time that these bacteria go into hiding, and it was just a common-sense concept that you let them go dormant and when they come back up again, you hit them again.' But 'the ‘off’ period may have been too long in humans,' Dr. Kotsoris says, and that could be why the pattern didn’t help some patients.") Wobei natürlich das optimale Timing in vitro anders sein kann als in vivo.
Quelle: In Test Tube, ‘Pulse-Doses’ Of Antibiotic Wipe Out Lyme Disease Bacteria Persisters, June 12, 2015, Carey Goldberg, http://commonhealth.wbur.org/2015/06/lym...ster-pulse